A New Era of - Regenerative Medicine

Price: $650

100% Natural. No animal products. GMO Free.
Purified Cord Blood MSC Exosomes in saline.

Cellgenic Exosomes is a purified xeno-free, chemically defined, cell-free cord blood MSC derived exosome re-suspended in 0.9% normal saline.Contains over 5 billion purified MSC exosomes per vial.

Product description:

Since few transplanted cells persist in vivo, the beneficial effects of cell therapy may lie in the secreted factors being the active component of this treatment.

A key part of paracrine secretion is Exosomes, which are membrane vesicles that are stored intracellularly in endosomal compartments and are secreted when these structures fuse with the cell plasma membrane.

Exosomes contain protein, DNA, and RNA, thus making them an attractive vector of paracrine signals delivered by stem cells.
Exosomes may also be “loaded” with predetermined proteins and nucleic acid to achieve a desired effect (1).
Exosomes can be stored as an “off-the-shelf” product having the potential for circumventing many of the limitations of\viable cells for therapeutic applications in regenerative medicine.
In vitro, exosomes from pre-adipocytes stimulate cell proliferation in a wound healing model.
In vivo, adipose-graft derived exosomes have been shown to be a promising tool for skin repair and remodeling (2)

Components of Cellgenic Exosomes

Exosomes, Cytokines, Chemokines, Growth Factors, Hyaluronic Acid (HA)

Exosomes can Deliver these signals

Anti-Apoptotic, Anti-Fibrotic, Pro-Angiogenic, Pro-Differentiation, Pro-Proliferation, Immunomodulatory, Immune Privileged

Maximum Safety and Quality Control

Sterile-filtered without radiation, No cryoprotectant or dilutants ever usedEndotoxin and USP <71> testing on all lots. Non Expanded/Non Cultured 100% pure liquid allogeneic secretion. Maximum bioavailability. Non-nucleated cellMinimal Manipulated

Quality Compliance & Donor Screening

Cellgenic Exosomes is procured and processed in the United States according to standards and regulations established by the American Association of Tissue Banks (AATB), the United States Food & Drug Administration (FDA). All local donors. Donor ethics and non-reactive FDA approved serological screening includes:

Donor Consent Prior
to Collections

HCV (Hepatitis C Antibody)
HBsAG (Hepatitis B Surface Antigen)
HIV 1/11-Ab (HIV Nucleic Acid Test)
HBcAb (Hepatitis B core Antibody)
HCV NAt (HCV Nucleic Acid Test)

RECEIVING CELLGENIC EXOSOMES

DRY ICE

Cellgenic Flox Exosomes is a human tissue allograft that is received in a box on dry ice.
CHECK LABEL

Before opening the box, check the label.
EXPIRY DATE

You must use graft before the expiry date or transfer to a freezer.
STORE

Move to a Freezer and store at -20C or lower.

Preparation and Dilution

The necessary materials for the procedure are:

Cellgenic Exosomes Vials
3cc Syringe
18 Gauge Needle
22 to 27 Gauge Needle
The Dilutant of choice

Aceptable Dilutants:

Normal saline
1% preservative free pain lidocaine
Platelet Rich Plasma

Prohibited Dilutants:

Glycerol
Glucose Solutions (eg.D5NS)
Epinephrine
Lidocaine/marcaine with preservatives
Lidocaine/Marcaine in Joints
Chemical Debridement (eg. Santyl)

PREPARATION & MIXING

STEP BY STEP PROCEDURE

Removed the package from freezer. Cut the Package.
Defrost vial by holding still in hand for 3-5 minutes.
(Do not shake the vial)
Fill syringe with dilutant. (Typically 1:1 ratio)
Draw Cellgenic Exosomes into syringe with 18G Needle.
Use a 22 to 27G needle for implantation.

POST IMPLANTATION PROTOCOL

Stimulation of inflammation of tissue is desired to increase success:

No Anti Inflammatories
No Aspirin
Minimize Immobilization (joints)
No Icing
Protected Active rehabilitation is recommended.